Cell Biology Notes Alzheimer's Disease / ID: 723706

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ID number:723706

Author: Anonymous author (14)

Evaluation:

Published: 03.06.2003.

Language: English

Level: Secondary school

Literature: n/a

References: Not used

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Alzheimer's disease
1) Primary Source - "FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a y-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the y-Secretase Cleavage Complex"
Alzheimer's disease (AD) causes mutations in presenilin-1 (PS1) and presenilin -2 (PS2) that increase the formation of amyloid B-peptides (AB). AB is formed by increasing the cleavage of B-amyloid precursor protein (APP), and the cleavage of APP is performed by y-secretase. So in simpler terms, AB peptides are formed by the cleavage of APP by B- and y- secretase.…

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Cell Biology Notes Alzheimer's Disease