Disease States Involving Disturbances of Homeostasis

7. Snake Bite - In Australia, the Common Brown, Tiger, Dugite, Taipan and Rough Scaled. The venom causes defibrination (White J., 1987).
Pathological Consequences of Defective Blood Clotting.
The pathological consequence of defective blood clotting is haemorrhage or abnormal bleeding. The most common sites for this bleeding include the gastointestinal tract, shin, eyes, urinary tract, gums, tooth sockets after extraction, joints and the brain.
In haemophilia, haemarthrosis may occur with ambulation and may lead to degenerative joint changes. By 3 - 4 yrs of age 90% of children have experienced persistent bleeding. Severe bleeding may constitute life threatening emergencies.
Disseminated Vascular Coagulation (DIC) leads to massive intravascular coagulation with rapid utilisation of the clotting factors, including prothrombin, fibrinogen and platelets in the same manner as occurs normally. If the utilisation proceeds more rapidly than the repletion of these factors, the serum becomes totally uncoagulable and severe bleeding may ensue. This is exacerbated by the secondary fibrinolysis that is activated.
Current Therapies for Managing Defective Blood Clotting.
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